Multiple Sclerosis

An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Also Known As:

Disseminated Sclerosis; Sclerosis, Multiple; MS (Multiple Sclerosis); Multiple Sclerosis, Acute Fulminating; Sclerosis, Disseminated

Nervous System Diseases: 14178
- Demyelinating Diseases: 9131
  - CNS Demyelinating Autoimmune Diseases
    - Multiple Sclerosis: 35483
- Autoimmune Diseases of the Nervous System: 1461
  - CNS Demyelinating Autoimmune Diseases
    - Multiple Sclerosis: 35483
Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Autoimmune Diseases of the Nervous System: 1461
    - CNS Demyelinating Autoimmune Diseases
      - Multiple Sclerosis: 35483

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Drug/Important Bio-Agent (IBA)